This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for SEPHS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEPHS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEPHS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:13,099,052–13,100,750 | 249.1 kb | Distal (>10kb) Multiome | 675 | |
| chr10:13,120,751–13,121,780 | 227.0 kb | Distal (>10kb) Multiome | 155 | |
| chr10:13,161,059–13,162,040 | 186.8 kb | Distal (>10kb) Multiome | 746 | |
| chr10:13,299,293–13,300,384 | 48.3 kb | Distal (>10kb) Multiome | 850 | |
| chr10:13,302,089–13,302,853 | 45.9 kb | Distal (>10kb) Multiome | 807 | |
| chr10:13,347,195–13,348,918 | 130 bp | At TSS Multiome | 753 | |
| chr10:13,349,410–13,350,393 | 1.7 kb | Proximal (<10kb) Multiome | 432 | |
| chr10:13,351,365–13,351,877 | 3.3 kb | Proximal (<10kb) Multiome | 105 | |
| chr10:13,352,639–13,352,790 | 4.4 kb | Proximal (<10kb) | 75 | |
| chr10:13,440,173–13,440,755 | 92.3 kb | Distal (>10kb) Multiome | 414 | |
| chr10:13,528,519–13,529,578 | 180.8 kb | Distal (>10kb) Multiome | 267 | |
| chr10:13,586,728–13,587,229 | 238.6 kb | Distal (>10kb) Multiome | 812 |
Genomic view of the SEPHS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.