Predicted to enable identical protein binding activity; signaling receptor binding activity; and transmembrane signaling receptor activity. Involved in cellular response to vascular endothelial growth factor stimulus; negative regulation of cell adhesion involved in sprouting angiogenesis; and negative regulation of signal transduction. Predicted to be located in axon and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SEMA6A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEMA6A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEMA6A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:116,343,834–116,344,383 | 230.7 kb | Distal (>10kb) Multiome | 101 | |
| chr5:116,361,097–116,362,155 | 213.2 kb | Distal (>10kb) Multiome | 208 | |
| chr5:116,559,039–116,560,382 | 15.4 kb | Distal (>10kb) Multiome | 241 | |
| chr5:116,565,193–116,565,423 | 9.4 kb | Proximal (<10kb) | 30 | |
| chr5:116,571,947–116,575,430 | 1.9 kb | Proximal (<10kb) Multiome | 841 | |
| chr5:116,575,628–116,576,752 | 1.5 kb | Proximal (<10kb) Multiome | 439 | |
| chr5:116,662,956–116,663,777 | 88.5 kb | Distal (>10kb) Multiome | 107 | |
| chr5:116,773,703–116,774,539 | 199.4 kb | Distal (>10kb) Multiome HiCAR | 283 | |
| chr5:116,777,987–116,778,688 | 203.4 kb | Distal (>10kb) Multiome HiCAR | 159 | |
| chr5:116,863,972–116,865,177 | 289.7 kb | Distal (>10kb) Multiome HiCAR | 571 | |
| chr5:116,945,611–116,946,249 | 371.1 kb | Distal (>10kb) Multiome HiCAR | 89 | |
| chr5:117,809,062–117,809,864 | 1234.6 kb | Distal (>10kb) Multiome HiCAR | 92 |
Genomic view of the SEMA6A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.