The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SEC61B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC61B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC61B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:98,943,613–98,944,680 | 278.3 kb | Distal (>10kb) Multiome | 250 | |
| chr9:98,974,780–98,975,407 | 247.2 kb | Distal (>10kb) Multiome | 363 | |
| chr9:98,998,541–98,999,328 | 223.3 kb | Distal (>10kb) Multiome | 303 | |
| chr9:99,104,286–99,106,069 | 117.3 kb | Distal (>10kb) Multiome | 701 | |
| chr9:99,184,218–99,185,128 | 37.5 kb | Distal (>10kb) Multiome | 374 | |
| chr9:99,221,253–99,222,741 | 230 bp | At TSS Multiome | 903 | |
| chr9:99,477,208–99,478,003 | 255.3 kb | Distal (>10kb) Multiome | 35 | |
| chr9:99,508,252–99,508,962 | 286.4 kb | Distal (>10kb) Multiome | 42 | |
| chr9:99,819,265–99,820,671 | 597.7 kb | Distal (>10kb) Multiome HiCAR | 934 | |
| chr9:99,834,356–99,835,065 | 612.4 kb | Distal (>10kb) Multiome HiCAR | 66 | |
| chr9:100,426,556–100,428,087 | 1205.0 kb | Distal (>10kb) Multiome HiCAR | 680 |
Genomic view of the SEC61B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.