The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for SEC31A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC31A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC31A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:82,667,793–82,668,466 | 232.4 kb | Distal (>10kb) Multiome | 123 | |
| chr4:82,716,050–82,716,644 | 184.1 kb | Distal (>10kb) Multiome | 173 | |
| chr4:82,739,190–82,739,774 | 161.0 kb | Distal (>10kb) Multiome | 317 | |
| chr4:82,797,244–82,798,074 | 103.1 kb | Distal (>10kb) Multiome | 243 | |
| chr4:82,798,169–82,799,103 | 101.7 kb | Distal (>10kb) Multiome | 368 | |
| chr4:82,889,873–82,890,221 | 992 bp | At TSS | 106 | |
| chr4:82,890,719–82,891,825 | 9.3 kb | Proximal (<10kb) Multiome | 1005 | |
| chr4:82,899,856–82,901,464 | 165 bp | At TSS Multiome | 977 | |
| chr4:83,010,137–83,011,179 | 110.2 kb | Distal (>10kb) Multiome | 601 | |
| chr4:83,012,161–83,013,775 | 112.5 kb | Distal (>10kb) Multiome | 913 | |
| chr4:83,034,341–83,035,668 | 134.5 kb | Distal (>10kb) Multiome | 993 | |
| chr4:83,109,433–83,110,778 | 209.2 kb | Distal (>10kb) Multiome | 591 |
Genomic view of the SEC31A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.