This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for SEC11A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC11A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC11A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:84,570,159–84,571,300 | 145.2 kb | Distal (>10kb) Multiome | 730 | |
| chr15:84,587,808–84,588,502 | 128.0 kb | Distal (>10kb) Multiome | 357 | |
| chr15:84,600,331–84,601,554 | 115.2 kb | Distal (>10kb) Multiome | 827 | |
| chr15:84,603,386–84,604,192 | 112.4 kb | Distal (>10kb) Multiome | 119 | |
| chr15:84,630,983–84,631,898 | 84.8 kb | Distal (>10kb) Multiome | 649 | |
| chr15:84,633,275–84,634,337 | 82.4 kb | Distal (>10kb) Multiome | 621 | |
| chr15:84,653,715–84,654,595 | 61.8 kb | Distal (>10kb) Multiome | 788 | |
| chr15:84,657,788–84,658,916 | 57.8 kb | Distal (>10kb) Multiome | 591 | |
| chr15:84,715,472–84,717,226 | 165 bp | At TSS Multiome | 972 | |
| chr15:84,734,887–84,735,749 | 19.0 kb | Distal (>10kb) Multiome | 614 | |
| chr15:84,747,459–84,749,457 | 32.3 kb | Distal (>10kb) Multiome | 852 | |
| chr15:84,816,861–84,818,557 | 101.6 kb | Distal (>10kb) Multiome | 375 | |
| chr15:84,928,071–84,928,522 | 212.2 kb | Distal (>10kb) Multiome | 445 | |
| chr15:84,960,290–84,961,237 | 244.6 kb | Distal (>10kb) Multiome | 222 | |
| chr15:84,980,278–84,982,611 | 265.1 kb | Distal (>10kb) Multiome | 1106 |
Genomic view of the SEC11A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.