Enables damaged DNA binding activity and snoRNA binding activity. Involved in several processes, including cellular response to UV; gene expression; and mitotic G1 DNA damage checkpoint signaling. Located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SDE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:225,474,969–225,475,612 | 524.2 kb | Distal (>10kb) Multiome HiCAR | 742 | |
| chr1:225,754,870–225,755,548 | 244.2 kb | Distal (>10kb) Multiome | 382 | |
| chr1:225,768,775–225,769,570 | 230.1 kb | Distal (>10kb) Multiome | 313 | |
| chr1:225,771,884–225,772,638 | 227.0 kb | Distal (>10kb) Multiome | 488 | |
| chr1:225,777,167–225,778,412 | 221.6 kb | Distal (>10kb) Multiome | 942 | |
| chr1:225,809,711–225,811,548 | 189.2 kb | Distal (>10kb) Multiome | 654 | |
| chr1:225,845,424–225,846,556 | 153.4 kb | Distal (>10kb) Multiome | 416 | |
| chr1:225,881,255–225,884,173 | 117.0 kb | Distal (>10kb) Multiome | 879 | |
| chr1:225,888,552–225,889,596 | 110.1 kb | Distal (>10kb) Multiome | 185 | |
| chr1:225,898,735–225,899,922 | 99.8 kb | Distal (>10kb) Multiome | 335 | |
| chr1:225,903,782–225,904,454 | 95.3 kb | Distal (>10kb) Multiome | 40 | |
| chr1:225,908,825–225,909,327 | 90.3 kb | Distal (>10kb) Multiome | 101 | |
| chr1:225,910,978–225,911,799 | 88.0 kb | Distal (>10kb) Multiome | 344 | |
| chr1:225,923,776–225,924,773 | 75.0 kb | Distal (>10kb) Multiome | 960 | |
| chr1:225,939,444–225,939,998 | 59.7 kb | Distal (>10kb) Multiome | 62 | |
| chr1:225,945,518–225,946,038 | 53.6 kb | Distal (>10kb) Multiome | 172 | |
| chr1:225,948,616–225,949,435 | 50.3 kb | Distal (>10kb) Multiome | 175 | |
| chr1:225,957,776–225,958,797 | 41.0 kb | Distal (>10kb) Multiome | 175 | |
| chr1:225,999,043–226,000,159 | 155 bp | At TSS Multiome | 969 | |
| chr1:226,002,756–226,003,086 | 3.4 kb | Proximal (<10kb) | 416 | |
| chr1:226,061,587–226,063,333 | 63.2 kb | Distal (>10kb) Multiome | 976 | |
| chr1:226,082,913–226,084,135 | 84.3 kb | Distal (>10kb) Multiome | 852 | |
| chr1:226,109,567–226,111,083 | 110.7 kb | Distal (>10kb) Multiome | 768 | |
| chr1:226,121,192–226,122,943 | 122.5 kb | Distal (>10kb) Multiome | 840 | |
| chr1:226,125,045–226,125,680 | 126.0 kb | Distal (>10kb) Multiome | 373 | |
| chr1:226,186,167–226,187,132 | 187.5 kb | Distal (>10kb) Multiome | 939 | |
| chr1:226,210,358–226,211,556 | 211.6 kb | Distal (>10kb) Multiome | 262 | |
| chr1:226,214,653–226,215,688 | 216.1 kb | Distal (>10kb) Multiome | 145 | |
| chr1:226,222,744–226,224,297 | 224.1 kb | Distal (>10kb) Multiome | 635 | |
| chr1:226,227,753–226,229,876 | 229.1 kb | Distal (>10kb) Multiome | 240 |
Genomic view of the SDE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.