Transcription factors with Perturb-seq knockdown data for SDCBP2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDCBP2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDCBP2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:1,061,388–1,061,918 | 263.8 kb | Distal (>10kb) Multiome | 105 | |
| chr20:1,118,327–1,119,071 | 206.8 kb | Distal (>10kb) Multiome | 1066 | |
| chr20:1,184,818–1,186,197 | 139.6 kb | Distal (>10kb) Multiome | 557 | |
| chr20:1,225,365–1,226,806 | 99.6 kb | Distal (>10kb) Multiome | 616 | |
| chr20:1,266,029–1,266,958 | 59.0 kb | Distal (>10kb) Multiome | 499 | |
| chr20:1,300,911–1,301,500 | 24.1 kb | Distal (>10kb) Multiome | 171 | |
| chr20:1,313,163–1,313,790 | 11.9 kb | Distal (>10kb) Multiome | 428 | |
| chr20:1,325,008–1,326,107 | 3 bp | At TSS Multiome | 901 | |
| chr20:1,392,628–1,393,457 | 67.7 kb | Distal (>10kb) Multiome | 799 | |
| chr20:1,427,438–1,428,145 | 102.4 kb | Distal (>10kb) Multiome | 285 | |
| chr20:1,466,316–1,467,471 | 141.5 kb | Distal (>10kb) Multiome | 1054 |
Genomic view of the SDCBP2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.