This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for SCYL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCYL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCYL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:169,687,392–169,688,201 | 206.1 kb | Distal (>10kb) Multiome | 176 | |
| chr1:169,794,430–169,795,475 | 99.0 kb | Distal (>10kb) Multiome | 846 | |
| chr1:169,890,830–169,891,797 | 2.1 kb | Proximal (<10kb) | 282 | |
| chr1:169,893,205–169,894,843 | 125 bp | At TSS Multiome | 987 | |
| chr1:169,899,265–169,900,114 | 5.4 kb | Proximal (<10kb) | 105 | |
| chr1:169,902,374–169,902,522 | 8.5 kb | Proximal (<10kb) | 1 | |
| chr1:169,902,801–169,903,048 | 8.9 kb | Proximal (<10kb) | 22 | |
| chr1:170,003,185–170,004,035 | 109.7 kb | Distal (>10kb) Multiome | 99 | |
| chr1:170,074,099–170,075,307 | 180.8 kb | Distal (>10kb) Multiome | 740 | |
| chr1:170,145,039–170,147,156 | 252.2 kb | Distal (>10kb) Multiome | 368 | |
| chr1:170,531,220–170,532,737 | 638.2 kb | Distal (>10kb) Multiome HiCAR | 916 | |
| chr1:171,396,571–171,398,669 | 1503.2 kb | Distal (>10kb) Multiome HiCAR | 230 |
Genomic view of the SCYL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.