Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SCRN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCRN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCRN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:47,648,863–47,650,987 | 191.6 kb | Distal (>10kb) Multiome | 1152 | |
| chr17:47,693,705–47,695,210 | 146.8 kb | Distal (>10kb) Multiome | 619 | |
| chr17:47,733,002–47,733,810 | 108.0 kb | Distal (>10kb) Multiome | 366 | |
| chr17:47,789,633–47,790,336 | 51.2 kb | Distal (>10kb) Multiome | 395 | |
| chr17:47,831,256–47,831,955 | 9.7 kb | Proximal (<10kb) Multiome | 856 | |
| chr17:47,840,790–47,841,702 | 29 bp | At TSS Multiome | 833 | |
| chr17:47,843,132–47,843,319 | 1.9 kb | Proximal (<10kb) | 271 | |
| chr17:47,847,253–47,848,429 | 6.5 kb | Proximal (<10kb) Multiome | 193 | |
| chr17:47,850,617–47,851,614 | 9.9 kb | Proximal (<10kb) Multiome | 694 | |
| chr17:47,895,361–47,896,955 | 54.9 kb | Distal (>10kb) Multiome HiCAR | 1031 | |
| chr17:47,902,020–47,902,508 | 60.9 kb | Distal (>10kb) Multiome | 101 | |
| chr17:47,941,283–47,941,880 | 100.3 kb | Distal (>10kb) Multiome | 958 | |
| chr17:47,970,487–47,971,547 | 129.7 kb | Distal (>10kb) Multiome HiCAR | 1061 | |
| chr17:48,023,351–48,024,470 | 182.3 kb | Distal (>10kb) Multiome | 591 | |
| chr17:48,024,599–48,025,777 | 184.0 kb | Distal (>10kb) Multiome | 759 | |
| chr17:48,026,284–48,026,933 | 185.4 kb | Distal (>10kb) Multiome | 543 | |
| chr17:48,047,576–48,049,198 | 207.0 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:48,053,836–48,055,155 | 213.2 kb | Distal (>10kb) Multiome | 327 | |
| chr17:48,055,581–48,056,000 | 214.7 kb | Distal (>10kb) Multiome | 337 | |
| chr17:48,100,593–48,101,963 | 260.2 kb | Distal (>10kb) Multiome | 974 | |
| chr17:48,107,198–48,108,007 | 266.4 kb | Distal (>10kb) Multiome | 841 |
Genomic view of the SCRN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.