This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for SCRN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCRN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCRN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:29,793,536–29,794,092 | 196.1 kb | Distal (>10kb) Multiome | 300 | |
| chr7:29,805,967–29,807,849 | 183.4 kb | Distal (>10kb) Multiome | 418 | |
| chr7:29,883,518–29,884,842 | 105.7 kb | Distal (>10kb) Multiome | 244 | |
| chr7:29,988,427–29,988,700 | 1.1 kb | Proximal (<10kb) | 450 | |
| chr7:29,988,902–29,990,326 | 33 bp | At TSS Multiome | 631 | |
| chr7:30,026,273–30,027,418 | 37.0 kb | Distal (>10kb) Multiome | 750 | |
| chr7:30,027,667–30,029,334 | 38.6 kb | Distal (>10kb) Multiome | 888 | |
| chr7:30,134,508–30,136,317 | 145.0 kb | Distal (>10kb) Multiome | 663 | |
| chr7:30,284,014–30,286,043 | 294.7 kb | Distal (>10kb) Multiome | 943 |
Genomic view of the SCRN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.