Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SCLY. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCLY upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCLY, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:237,966,278–237,967,676 | 94.2 kb | Distal (>10kb) Multiome | 861 | |
| chr2:238,060,279–238,061,878 | 140 bp | At TSS Multiome | 970 | |
| chr2:238,098,121–238,098,760 | 37.5 kb | Distal (>10kb) Multiome | 222 | |
| chr2:238,158,343–238,159,417 | 97.9 kb | Distal (>10kb) Multiome | 343 | |
| chr2:238,203,020–238,204,239 | 142.7 kb | Distal (>10kb) Multiome | 702 | |
| chr2:238,234,336–238,234,816 | 173.5 kb | Distal (>10kb) Multiome | 543 | |
| chr2:238,238,732–238,241,847 | 179.1 kb | Distal (>10kb) Multiome | 1072 | |
| chr2:238,287,738–238,289,462 | 227.9 kb | Distal (>10kb) Multiome | 893 | |
| chr2:238,289,660–238,290,518 | 229.4 kb | Distal (>10kb) Multiome | 315 | |
| chr2:238,319,822–238,321,188 | 259.4 kb | Distal (>10kb) Multiome | 623 |
Genomic view of the SCLY locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.