Enables RNA binding activity. Involved in spliceosomal complex assembly. Located in nuclear body and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SCAF11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCAF11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCAF11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:45,726,865–45,728,208 | 263.0 kb | Distal (>10kb) Multiome | 991 | |
| chr12:45,728,446–45,731,126 | 261.6 kb | Distal (>10kb) Multiome | 1023 | |
| chr12:45,986,865–45,987,268 | 3.3 kb | Proximal (<10kb) | 78 | |
| chr12:45,989,594–45,992,639 | 117 bp | At TSS Multiome | 1242 | |
| chr12:46,267,263–46,270,142 | 278.5 kb | Distal (>10kb) Multiome | 1114 |
Genomic view of the SCAF11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.