Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SBK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SBK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SBK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:28,211,165–28,212,644 | 80.5 kb | Distal (>10kb) Multiome | 960 | |
| chr16:28,267,361–28,267,924 | 24.9 kb | Distal (>10kb) Multiome | 36 | |
| chr16:28,277,564–28,278,417 | 14.6 kb | Distal (>10kb) Multiome | 598 | |
| chr16:28,291,632–28,293,697 | 1.0 kb | Proximal (<10kb) Multiome | 578 | |
| chr16:28,491,428–28,492,451 | 199.6 kb | Distal (>10kb) Multiome | 879 | |
| chr16:28,553,780–28,554,756 | 261.6 kb | Distal (>10kb) Multiome HiCAR | 995 |
Genomic view of the SBK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.