Predicted to enable microtubule binding activity. Predicted to be active in microtubule cytoskeleton; nucleus; and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SAXO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAXO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAXO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:82,044,186–82,047,995 | 216.7 kb | Distal (>10kb) Multiome | 848 | |
| chr15:82,262,203–82,263,651 | 100 bp | At TSS Multiome | 696 | |
| chr15:82,266,566–82,266,930 | 3.8 kb | Proximal (<10kb) | 13 | |
| chr15:82,267,107–82,267,477 | 4.3 kb | Proximal (<10kb) | 64 | |
| chr15:82,272,187–82,272,526 | 9.4 kb | Proximal (<10kb) | 62 |
Genomic view of the SAXO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.