Transcription factors with Perturb-seq knockdown data for SAMD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAMD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAMD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:130,017,884–130,021,374 | 346.8 kb | Distal (>10kb) Multiome | 794 | |
| chr6:130,215,236–130,215,977 | 149.8 kb | Distal (>10kb) Multiome | 178 | |
| chr6:130,216,190–130,217,089 | 548 bp | At TSS | 94 | |
| chr6:130,223,543–130,223,918 | 7.9 kb | Proximal (<10kb) | 49 | |
| chr6:130,362,137–130,362,459 | 3.0 kb | Proximal (<10kb) | 171 | |
| chr6:130,364,977–130,367,032 | 1.1 kb | Proximal (<10kb) Multiome | 632 |
Genomic view of the SAMD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.