The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for S100A11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = S100A11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of S100A11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:151,762,987–151,763,859 | 273.5 kb | Distal (>10kb) Multiome | 848 | |
| chr1:151,790,055–151,791,612 | 246.4 kb | Distal (>10kb) Multiome | 953 | |
| chr1:151,839,238–151,840,386 | 197.2 kb | Distal (>10kb) Multiome | 493 | |
| chr1:151,909,150–151,910,123 | 127.4 kb | Distal (>10kb) Multiome | 983 | |
| chr1:151,936,340–151,937,120 | 100.1 kb | Distal (>10kb) Multiome HiCAR | 185 | |
| chr1:151,992,346–151,994,801 | 43.0 kb | Distal (>10kb) Multiome | 709 | |
| chr1:152,034,408–152,035,398 | 2.2 kb | Proximal (<10kb) Multiome | 590 | |
| chr1:152,035,632–152,036,032 | 971 bp | At TSS | 184 | |
| chr1:152,036,267–152,037,471 | 1 bp | At TSS Multiome | 586 | |
| chr1:152,038,343–152,038,653 | 1.3 kb | Proximal (<10kb) | 92 | |
| chr1:152,047,642–152,048,726 | 11.2 kb | Distal (>10kb) Multiome | 810 | |
| chr1:153,626,535–153,627,974 | 1590.5 kb | Distal (>10kb) Multiome HiCAR | 697 |
Genomic view of the S100A11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.