The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for S100A10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = S100A10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of S100A10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:151,721,370–151,721,843 | 272.3 kb | Distal (>10kb) Multiome | 186 | |
| chr1:151,762,987–151,763,859 | 230.4 kb | Distal (>10kb) Multiome | 848 | |
| chr1:151,790,055–151,791,612 | 203.3 kb | Distal (>10kb) Multiome | 953 | |
| chr1:151,839,238–151,840,386 | 154.1 kb | Distal (>10kb) Multiome | 493 | |
| chr1:151,909,150–151,910,123 | 84.3 kb | Distal (>10kb) Multiome | 983 | |
| chr1:151,936,340–151,937,120 | 56.9 kb | Distal (>10kb) Multiome HiCAR | 185 | |
| chr1:151,988,367–151,988,831 | 5.0 kb | Proximal (<10kb) | 397 | |
| chr1:151,992,346–151,994,801 | 155 bp | At TSS Multiome | 709 | |
| chr1:152,001,638–152,002,026 | 7.8 kb | Proximal (<10kb) | 242 | |
| chr1:152,034,408–152,035,398 | 40.9 kb | Distal (>10kb) Multiome | 590 | |
| chr1:152,036,267–152,037,471 | 43.1 kb | Distal (>10kb) Multiome | 586 | |
| chr1:152,047,642–152,048,726 | 54.3 kb | Distal (>10kb) Multiome | 810 |
Genomic view of the S100A10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.