Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for RPS6KC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPS6KC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPS6KC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:212,698,874–212,700,500 | 351.9 kb | Distal (>10kb) Multiome HiCAR | 710 | |
| chr1:212,791,461–212,792,424 | 259.4 kb | Distal (>10kb) Multiome | 1108 | |
| chr1:212,857,574–212,859,115 | 193.1 kb | Distal (>10kb) Multiome | 946 | |
| chr1:212,860,779–212,861,295 | 190.3 kb | Distal (>10kb) Multiome | 315 | |
| chr1:212,907,964–212,908,918 | 142.8 kb | Distal (>10kb) Multiome | 62 | |
| chr1:212,909,569–212,910,174 | 141.2 kb | Distal (>10kb) Multiome | 97 | |
| chr1:212,916,378–212,917,359 | 134.2 kb | Distal (>10kb) Multiome | 306 | |
| chr1:212,928,624–212,929,308 | 122.2 kb | Distal (>10kb) Multiome | 145 | |
| chr1:212,950,130–212,951,519 | 100.7 kb | Distal (>10kb) Multiome | 457 | |
| chr1:212,967,458–212,968,096 | 83.3 kb | Distal (>10kb) Multiome | 178 | |
| chr1:213,015,122–213,015,983 | 35.6 kb | Distal (>10kb) Multiome | 888 | |
| chr1:213,050,888–213,051,797 | 39 bp | At TSS Multiome | 880 | |
| chr1:213,060,938–213,061,148 | 9.7 kb | Proximal (<10kb) | 20 | |
| chr1:213,066,260–213,067,034 | 15.4 kb | Distal (>10kb) Multiome | 70 | |
| chr1:213,231,902–213,232,438 | 180.8 kb | Distal (>10kb) Multiome | 196 | |
| chr1:213,260,264–213,261,320 | 209.6 kb | Distal (>10kb) Multiome | 165 |
Genomic view of the RPS6KC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.