Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Part of transcription preinitiation complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RPRD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPRD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPRD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:150,066,903–150,067,886 | 296.5 kb | Distal (>10kb) Multiome | 986 | |
| chr1:150,149,493–150,150,439 | 214.1 kb | Distal (>10kb) Multiome | 448 | |
| chr1:150,162,838–150,163,636 | 200.9 kb | Distal (>10kb) Multiome | 550 | |
| chr1:150,213,532–150,214,095 | 150.4 kb | Distal (>10kb) Multiome | 441 | |
| chr1:150,234,435–150,235,519 | 129.4 kb | Distal (>10kb) Multiome | 725 | |
| chr1:150,235,635–150,236,696 | 127.9 kb | Distal (>10kb) Multiome | 905 | |
| chr1:150,255,443–150,256,199 | 108.4 kb | Distal (>10kb) Multiome | 441 | |
| chr1:150,256,563–150,257,324 | 107.1 kb | Distal (>10kb) Multiome | 223 | |
| chr1:150,257,589–150,258,594 | 106.0 kb | Distal (>10kb) Multiome | 233 | |
| chr1:150,259,728–150,260,778 | 104.0 kb | Distal (>10kb) Multiome | 362 | |
| chr1:150,268,574–150,269,453 | 95.0 kb | Distal (>10kb) Multiome | 785 | |
| chr1:150,281,629–150,283,038 | 81.7 kb | Distal (>10kb) Multiome | 503 | |
| chr1:150,293,680–150,294,144 | 70.3 kb | Distal (>10kb) Multiome | 755 | |
| chr1:150,313,761–150,314,506 | 50.1 kb | Distal (>10kb) Multiome | 108 | |
| chr1:150,321,137–150,321,825 | 42.6 kb | Distal (>10kb) Multiome | 806 | |
| chr1:150,363,368–150,364,980 | 145 bp | At TSS Multiome | 971 | |
| chr1:150,487,154–150,487,710 | 123.2 kb | Distal (>10kb) Multiome | 929 | |
| chr1:150,515,085–150,516,227 | 151.5 kb | Distal (>10kb) Multiome | 781 | |
| chr1:150,548,849–150,549,823 | 185.1 kb | Distal (>10kb) Multiome | 620 | |
| chr1:150,560,828–150,562,623 | 197.2 kb | Distal (>10kb) Multiome | 897 | |
| chr1:150,578,554–150,580,300 | 215.4 kb | Distal (>10kb) Multiome | 990 | |
| chr1:150,629,012–150,630,122 | 265.3 kb | Distal (>10kb) Multiome | 875 | |
| chr1:150,634,804–150,635,486 | 271.1 kb | Distal (>10kb) Multiome | 113 | |
| chr1:150,641,008–150,641,820 | 277.4 kb | Distal (>10kb) Multiome | 66 |
Genomic view of the RPRD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.