Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RPP30. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPP30 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPP30, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:90,856,822–90,858,669 | 14.1 kb | Distal (>10kb) Multiome | 536 | |
| chr10:90,871,123–90,872,607 | 227 bp | At TSS Multiome | 694 | |
| chr10:90,876,525–90,876,965 | 4.6 kb | Proximal (<10kb) | 15 | |
| chr10:90,921,025–90,921,678 | 49.3 kb | Distal (>10kb) Multiome | 546 | |
| chr10:90,925,309–90,926,027 | 53.8 kb | Distal (>10kb) Multiome | 268 | |
| chr10:91,050,425–91,051,051 | 178.7 kb | Distal (>10kb) Multiome | 138 | |
| chr10:91,162,157–91,164,240 | 291.1 kb | Distal (>10kb) Multiome | 793 |
Genomic view of the RPP30 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.