Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in centriolar satellite and nucleoplasm. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. Biomarker of autistic disorder. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RPP25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPP25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPP25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:74,695,758–74,696,387 | 260.7 kb | Distal (>10kb) Multiome | 775 | |
| chr15:74,720,336–74,720,840 | 236.1 kb | Distal (>10kb) Multiome | 16 | |
| chr15:74,725,773–74,726,537 | 230.6 kb | Distal (>10kb) Multiome | 607 | |
| chr15:74,759,107–74,760,837 | 196.4 kb | Distal (>10kb) Multiome | 637 | |
| chr15:74,761,837–74,762,260 | 194.6 kb | Distal (>10kb) Multiome | 34 | |
| chr15:74,770,975–74,771,578 | 185.5 kb | Distal (>10kb) Multiome HiCAR | 485 | |
| chr15:74,781,439–74,783,648 | 174.7 kb | Distal (>10kb) Multiome | 679 | |
| chr15:74,842,412–74,843,723 | 113.8 kb | Distal (>10kb) Multiome | 879 | |
| chr15:74,872,771–74,874,092 | 83.5 kb | Distal (>10kb) Multiome | 758 | |
| chr15:74,889,894–74,890,629 | 66.7 kb | Distal (>10kb) Multiome | 816 | |
| chr15:74,905,926–74,907,376 | 50.0 kb | Distal (>10kb) Multiome | 743 | |
| chr15:74,937,494–74,938,710 | 18.7 kb | Distal (>10kb) Multiome | 998 | |
| chr15:74,950,147–74,950,911 | 6.1 kb | Proximal (<10kb) Multiome | 326 | |
| chr15:74,954,536–74,955,001 | 2.0 kb | Proximal (<10kb) Multiome | 348 | |
| chr15:74,955,873–74,957,720 | 39 bp | At TSS Multiome | 776 | |
| chr15:74,958,363–74,959,586 | 1.8 kb | Proximal (<10kb) Multiome | 282 | |
| chr15:74,995,116–74,996,280 | 38.8 kb | Distal (>10kb) Multiome | 825 | |
| chr15:75,023,365–75,023,895 | 66.8 kb | Distal (>10kb) Multiome | 822 | |
| chr15:75,140,133–75,140,707 | 183.6 kb | Distal (>10kb) Multiome | 536 | |
| chr15:75,178,233–75,178,833 | 221.7 kb | Distal (>10kb) Multiome | 386 | |
| chr15:75,200,527–75,203,502 | 245.2 kb | Distal (>10kb) Multiome | 928 |
Genomic view of the RPP25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.