RPLP2
ribosomal protein lateral stalk subunit P2 | LP2, MGC71408, P2, RPP2, D11S2243E

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.46 Developmental clusters: GC3
Biological processes 20 terms
Expression (TPM)
RPLP2 — as a Regulated Gene

TFs regulating RPLP2 0 TFs

Transcription factors with Perturb-seq knockdown data for RPLP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPLP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RPLP2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPLP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:534,525–536,399 274.3 kb Distal (>10kb) Multiome 673
chr11:536,654–537,918 272.5 kb Distal (>10kb) Multiome 558
chr11:554,380–556,321 254.8 kb Distal (>10kb) Multiome 460
chr11:559,830–562,079 249.1 kb Distal (>10kb) Multiome 791
chr11:567,850–569,533 241.4 kb Distal (>10kb) Multiome 672
chr11:574,830–576,748 233.8 kb Distal (>10kb) Multiome 793
chr11:613,334–614,059 196.2 kb Distal (>10kb) Multiome 215
chr11:615,262–616,320 194.0 kb Distal (>10kb) Multiome 443
chr11:636,786–637,700 172.8 kb Distal (>10kb) Multiome 161
chr11:693,835–696,330 114.5 kb Distal (>10kb) Multiome 873
chr11:705,737–706,270 103.9 kb Distal (>10kb) Multiome 361
chr11:720,619–721,074 89.1 kb Distal (>10kb) Multiome 156
chr11:727,901–728,499 81.8 kb Distal (>10kb) Multiome 686
chr11:746,704–748,069 62.6 kb Distal (>10kb) Multiome 755
chr11:762,582–763,602 46.7 kb Distal (>10kb) Multiome 326
chr11:776,216–778,328 32.5 kb Distal (>10kb) Multiome 770
chr11:783,385–783,909 26.3 kb Distal (>10kb) Multiome 278
chr11:797,112–798,675 11.7 kb Distal (>10kb) Multiome 697
chr11:804,241–805,812 4.6 kb Proximal (<10kb) Multiome 725
chr11:808,894–810,402 235 bp At TSS Multiome 976
chr11:818,369–820,592 9.6 kb Proximal (<10kb) Multiome 749
chr11:826,980–828,116 17.6 kb Distal (>10kb) Multiome 662
chr11:828,933–831,262 20.4 kb Distal (>10kb) Multiome 491
chr11:832,323–833,565 22.9 kb Distal (>10kb) Multiome 562
chr11:842,034–843,556 32.7 kb Distal (>10kb) Multiome 794
chr11:843,773–845,220 34.5 kb Distal (>10kb) Multiome 664
chr11:849,082–850,270 39.8 kb Distal (>10kb) Multiome 229
chr11:910,337–911,591 101.0 kb Distal (>10kb) Multiome 754
chr11:925,038–926,264 115.9 kb Distal (>10kb) Multiome 689

Genome Browser

Genomic view of the RPLP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:524,525 – 936,264
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq