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DE-1.46

Submodule 11 genes

Cytosolic ribosomal subunit and translation machinery

This 11-gene module includes ribosomal proteins RPLP2, RPL22, RPL34, RPL35A, and RPS24, with strong enrichment for cytosolic ribosome structure, ribosomal subunits, and translation processes. Knockdown of SOX11 represses this module.

Key terms: cytoplasmic translation protein biosynthetic process translation protein metabolic process Notable genes: RPLP2 RPL22 RPL34 RPL35A RPS24 RPL41 RPL39 RPL21 Top TFs: SOX11

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (11)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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