Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RPL7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:73,008,165–73,009,389 | 284.8 kb | Distal (>10kb) Multiome | 699 | |
| chr8:73,092,506–73,093,728 | 200.5 kb | Distal (>10kb) Multiome | 249 | |
| chr8:73,174,013–73,174,795 | 119.2 kb | Distal (>10kb) Multiome | 447 | |
| chr8:73,285,133–73,286,577 | 7.8 kb | Proximal (<10kb) Multiome | 282 | |
| chr8:73,293,182–73,296,152 | 561 bp | At TSS Multiome | 1030 | |
| chr8:73,418,792–73,420,001 | 125.9 kb | Distal (>10kb) Multiome | 381 | |
| chr8:73,448,791–73,449,788 | 155.6 kb | Distal (>10kb) Multiome | 239 |
Genomic view of the RPL7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.