RPL28

ribosomal protein L28 | FLJ43307, L28, eL28

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Member of: DE-1 DE-1.1

Biological processes 34 terms

RNA binding (GO:0003723)RNA binding (GO:0003723)cell body (GO:0044297)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic ribonucleoprotein granule (GO:0036464)cytoplasmic translation (GO:0002181)cytoplasmic translation (GO:0002181)cytoplasmic translation (GO:0002181)cytosol (GO:0005829)cytosol (GO:0005829)cytosolic large ribosomal subunit (GO:0022625)cytosolic large ribosomal subunit (GO:0022625)cytosolic large ribosomal subunit (GO:0022625)cytosolic large ribosomal subunit (GO:0022625)cytosolic large ribosomal subunit (GO:0022625)cytosolic ribosome (GO:0022626)dendrite (GO:0030425)endoplasmic reticulum (GO:0005783)extracellular exosome (GO:0070062)membrane (GO:0016020)negative regulation of myoblast fusion (GO:1901740)protein binding (GO:0005515)ribosome (GO:0005840)spermatogenesis (GO:0007283)striated muscle contraction (GO:0006941)structural constituent of ribosome (GO:0003735)structural constituent of ribosome (GO:0003735)structural constituent of ribosome (GO:0003735)structural constituent of ribosome (GO:0003735)synapse (GO:0045202)translation (GO:0006412)translation (GO:0006412)translation (GO:0006412)

Expression (TPM)

TFs regulating RPL28 0 TFs

Transcription factors with Perturb-seq knockdown data for RPL28. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL28 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RPL28

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL28, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:55,086,246–55,087,525	298.8 kb	Distal (>10kb) Multiome	258
chr19:55,091,780–55,093,292	293.6 kb	Distal (>10kb) Multiome	208
chr19:55,095,398–55,095,977	290.1 kb	Distal (>10kb) Multiome	90
chr19:55,117,134–55,119,109	268.2 kb	Distal (>10kb) Multiome	881
chr19:55,146,210–55,148,117	239.0 kb	Distal (>10kb) Multiome	528
chr19:55,156,193–55,157,266	229.3 kb	Distal (>10kb) Multiome	317
chr19:55,160,567–55,161,360	225.2 kb	Distal (>10kb) Multiome	554
chr19:55,165,952–55,167,256	219.2 kb	Distal (>10kb) Multiome	719
chr19:55,173,717–55,174,287	211.9 kb	Distal (>10kb) Multiome	330
chr19:55,178,876–55,179,477	206.8 kb	Distal (>10kb) Multiome	479
chr19:55,216,490–55,217,227	169.1 kb	Distal (>10kb) Multiome	1077
chr19:55,257,751–55,259,635	126.7 kb	Distal (>10kb) Multiome	1054
chr19:55,279,599–55,280,933	105.7 kb	Distal (>10kb) Multiome	805
chr19:55,283,835–55,284,716	101.9 kb	Distal (>10kb) Multiome	242
chr19:55,301,640–55,302,240	84.0 kb	Distal (>10kb) Multiome HiCAR	448
chr19:55,338,676–55,340,358	46.4 kb	Distal (>10kb) Multiome	882
chr19:55,340,675–55,341,535	44.6 kb	Distal (>10kb) Multiome	368
chr19:55,353,720–55,354,487	31.8 kb	Distal (>10kb) Multiome	297
chr19:55,369,099–55,370,447	15.9 kb	Distal (>10kb) Multiome	383
chr19:55,383,539–55,384,553	2.0 kb	Proximal (<10kb) Multiome	374
chr19:55,384,697–55,386,560	215 bp	At TSS Multiome	903
chr19:55,406,950–55,408,675	22.1 kb	Distal (>10kb) Multiome	965
chr19:55,452,738–55,453,308	67.2 kb	Distal (>10kb) Multiome	339
chr19:55,460,784–55,462,230	75.9 kb	Distal (>10kb) Multiome	947
chr19:55,476,048–55,477,307	90.8 kb	Distal (>10kb) Multiome	1007
chr19:55,484,846–55,485,682	99.2 kb	Distal (>10kb) Multiome	594
chr19:55,503,638–55,504,310	118.1 kb	Distal (>10kb) Multiome	710
chr19:55,516,768–55,517,459	131.2 kb	Distal (>10kb) Multiome	583
chr19:55,536,923–55,537,366	151.3 kb	Distal (>10kb) Multiome	180
chr19:55,549,822–55,550,343	164.1 kb	Distal (>10kb) Multiome	396
chr19:55,580,080–55,581,090	194.9 kb	Distal (>10kb) Multiome	718
chr19:55,585,644–55,586,314	199.9 kb	Distal (>10kb) Multiome	370
chr19:55,586,698–55,587,594	201.4 kb	Distal (>10kb) Multiome	463
chr19:55,598,551–55,600,991	214.5 kb	Distal (>10kb) Multiome	1018
chr19:55,604,520–55,606,690	219.4 kb	Distal (>10kb) Multiome	820
chr19:55,623,637–55,625,055	238.6 kb	Distal (>10kb) Multiome	650
chr19:55,640,091–55,641,769	255.1 kb	Distal (>10kb) Multiome	821
chr19:55,642,197–55,644,356	257.6 kb	Distal (>10kb) Multiome	884
chr19:55,647,711–55,648,342	262.2 kb	Distal (>10kb) Multiome	671
chr19:55,652,138–55,653,078	266.5 kb	Distal (>10kb) Multiome	105
chr19:55,653,199–55,656,056	268.7 kb	Distal (>10kb) Multiome	1123
chr19:55,674,767–55,675,613	289.2 kb	Distal (>10kb) Multiome	765

Genome Browser

Genomic view of the RPL28 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.