This gene encodes a protein that shares high sequence similarity with ribosomal protein L26. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for RPL26L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL26L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL26L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:172,683,287–172,684,318 | 274.8 kb | Distal (>10kb) Multiome | 215 | |
| chr5:172,697,353–172,697,964 | 261.3 kb | Distal (>10kb) Multiome | 445 | |
| chr5:172,700,111–172,700,934 | 258.4 kb | Distal (>10kb) Multiome HiCAR | 131 | |
| chr5:172,765,066–172,765,738 | 193.5 kb | Distal (>10kb) Multiome | 748 | |
| chr5:172,769,970–172,772,642 | 187.7 kb | Distal (>10kb) Multiome | 1190 | |
| chr5:172,828,888–172,829,516 | 129.6 kb | Distal (>10kb) Multiome | 139 | |
| chr5:172,833,492–172,835,141 | 124.7 kb | Distal (>10kb) Multiome | 673 | |
| chr5:172,941,457–172,942,000 | 17.1 kb | Distal (>10kb) Multiome | 22 | |
| chr5:172,958,380–172,959,872 | 385 bp | At TSS Multiome | 868 | |
| chr5:172,983,384–172,984,597 | 24.9 kb | Distal (>10kb) Multiome | 848 | |
| chr5:173,055,699–173,057,854 | 98.4 kb | Distal (>10kb) Multiome | 1049 | |
| chr5:173,144,311–173,145,555 | 185.9 kb | Distal (>10kb) Multiome HiCAR | 967 | |
| chr5:173,234,580–173,235,384 | 276.1 kb | Distal (>10kb) Multiome | 307 | |
| chr5:173,245,361–173,246,026 | 286.8 kb | Distal (>10kb) Multiome | 109 |
Genomic view of the RPL26L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.