RPL18
ribosomal protein L18 | L18, eL18

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Member of: DE-1 DE-1.1 Developmental clusters: GC2
Biological processes 35 terms
RNA binding (GO:0003723)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic translation (GO:0002181)cytoplasmic translation (GO:0002181)cytoplasmic translation (GO:0002181)cytoplasmic translation (GO:0002181)cytoplasmic translation (GO:0002181)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosolic large ribosomal subunit (GO:0022625)cytosolic large ribosomal subunit (GO:0022625)cytosolic large ribosomal subunit (GO:0022625)cytosolic large ribosomal subunit (GO:0022625)cytosolic large ribosomal subunit (GO:0022625)cytosolic ribosome (GO:0022626)endoplasmic reticulum (GO:0005783)focal adhesion (GO:0005925)membrane (GO:0016020)negative regulation of myoblast fusion (GO:1901740)nucleus (GO:0005634)protein binding (GO:0005515)ribosome (GO:0005840)rough endoplasmic reticulum (GO:0005791)spermatogenesis (GO:0007283)striated muscle contraction (GO:0006941)structural constituent of ribosome (GO:0003735)structural constituent of ribosome (GO:0003735)structural constituent of ribosome (GO:0003735)structural constituent of ribosome (GO:0003735)structural constituent of ribosome (GO:0003735)translation (GO:0006412)translation (GO:0006412)translation (GO:0006412)
Expression (TPM)
RPL18 — as a Regulated Gene

TFs regulating RPL18 0 TFs

Transcription factors with Perturb-seq knockdown data for RPL18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RPL18

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:48,320,062–48,322,328 297.7 kb Distal (>10kb) Multiome 826
chr19:48,330,094–48,330,787 288.9 kb Distal (>10kb) Multiome 460
chr19:48,332,701–48,333,506 286.3 kb Distal (>10kb) Multiome 615
chr19:48,333,584–48,334,372 285.1 kb Distal (>10kb) Multiome 554
chr19:48,363,062–48,364,710 255.0 kb Distal (>10kb) Multiome 940
chr19:48,390,663–48,391,935 227.6 kb Distal (>10kb) Multiome 816
chr19:48,397,916–48,399,301 220.3 kb Distal (>10kb) Multiome 619
chr19:48,399,411–48,400,900 218.6 kb Distal (>10kb) Multiome 548
chr19:48,414,121–48,416,085 203.6 kb Distal (>10kb) Multiome 298
chr19:48,445,379–48,446,456 173.3 kb Distal (>10kb) Multiome 845
chr19:48,468,758–48,470,027 150.0 kb Distal (>10kb) Multiome 860
chr19:48,490,661–48,494,449 127.8 kb Distal (>10kb) Multiome 633
chr19:48,500,898–48,503,050 117.1 kb Distal (>10kb) Multiome 656
chr19:48,510,624–48,511,212 108.4 kb Distal (>10kb) Multiome 268
chr19:48,513,480–48,514,294 105.3 kb Distal (>10kb) Multiome 585
chr19:48,614,318–48,615,255 4.3 kb Proximal (<10kb) Multiome 524
chr19:48,618,726–48,619,869 176 bp At TSS Multiome 1012
chr19:48,623,839–48,624,688 5.0 kb Proximal (<10kb) Multiome 529
chr19:48,629,369–48,631,306 10.9 kb Distal (>10kb) Multiome 402
chr19:48,634,242–48,636,244 16.5 kb Distal (>10kb) Multiome 868
chr19:48,636,802–48,639,603 19.2 kb Distal (>10kb) Multiome 956
chr19:48,645,454–48,647,163 27.4 kb Distal (>10kb) Multiome 750
chr19:48,675,421–48,675,873 56.4 kb Distal (>10kb) Multiome 415
chr19:48,695,830–48,697,033 76.9 kb Distal (>10kb) Multiome 253
chr19:48,713,646–48,714,846 95.1 kb Distal (>10kb) Multiome 719
chr19:48,716,551–48,717,038 97.7 kb Distal (>10kb) Multiome 241
chr19:48,720,420–48,721,301 101.7 kb Distal (>10kb) Multiome 689
chr19:48,735,001–48,735,602 116.1 kb Distal (>10kb) Multiome 161
chr19:48,738,441–48,739,812 119.7 kb Distal (>10kb) Multiome 743
chr19:48,741,194–48,741,939 122.4 kb Distal (>10kb) Multiome 350
chr19:48,746,830–48,747,395 127.9 kb Distal (>10kb) Multiome 402
chr19:48,752,314–48,753,547 133.8 kb Distal (>10kb) Multiome 545
chr19:48,795,165–48,795,736 176.3 kb Distal (>10kb) Multiome 724
chr19:48,806,734–48,807,478 187.8 kb Distal (>10kb) Multiome 452
chr19:48,810,774–48,811,494 191.8 kb Distal (>10kb) Multiome 662
chr19:48,812,048–48,813,099 193.3 kb Distal (>10kb) Multiome 603
chr19:48,829,998–48,830,690 211.1 kb Distal (>10kb) Multiome 55
chr19:48,835,571–48,838,073 216.6 kb Distal (>10kb) Multiome 621
chr19:48,872,000–48,873,835 253.2 kb Distal (>10kb) Multiome 987
chr19:48,895,958–48,896,628 277.1 kb Distal (>10kb) Multiome 207
chr19:48,899,782–48,900,620 281.1 kb Distal (>10kb) Multiome 710

Genome Browser

Genomic view of the RPL18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:48,310,062 – 48,910,620
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact