Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for RPL15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:23,701,633–23,702,476 | 215.2 kb | Distal (>10kb) Multiome | 210 | |
| chr3:23,805,437–23,807,461 | 111.2 kb | Distal (>10kb) Multiome | 636 | |
| chr3:23,809,943–23,811,474 | 106.6 kb | Distal (>10kb) Multiome | 685 | |
| chr3:23,916,365–23,917,803 | 104 bp | At TSS Multiome | 1082 | |
| chr3:23,921,007–23,921,435 | 3.9 kb | Proximal (<10kb) | 221 | |
| chr3:23,921,593–23,922,234 | 4.5 kb | Proximal (<10kb) | 67 | |
| chr3:23,922,421–23,923,129 | 5.3 kb | Proximal (<10kb) | 17 | |
| chr3:23,938,713–23,939,267 | 21.8 kb | Distal (>10kb) Multiome | 172 | |
| chr3:23,944,552–23,946,922 | 27.9 kb | Distal (>10kb) Multiome | 1112 | |
| chr3:23,953,236–23,954,388 | 36.6 kb | Distal (>10kb) Multiome | 152 |
Genomic view of the RPL15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.