Enables D-ribulose-phosphate 3-epimerase activity; metal ion binding activity; and protein homodimerization activity. Involved in carbohydrate metabolic process and pentose-phosphate shunt. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RPE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:209,771,427–209,772,913 | 230.7 kb | Distal (>10kb) Multiome | 849 | |
| chr2:209,773,211–209,773,954 | 229.0 kb | Distal (>10kb) Multiome | 123 | |
| chr2:209,817,604–209,818,340 | 184.6 kb | Distal (>10kb) Multiome | 183 | |
| chr2:209,960,058–209,961,333 | 41.7 kb | Distal (>10kb) Multiome | 269 | |
| chr2:209,985,387–209,986,656 | 16.8 kb | Distal (>10kb) Multiome | 197 | |
| chr2:209,994,084–209,994,343 | 8.3 kb | Proximal (<10kb) | 16 | |
| chr2:210,002,022–210,003,279 | 43 bp | At TSS Multiome | 811 | |
| chr2:210,009,853–210,010,007 | 7.2 kb | Proximal (<10kb) | 41 | |
| chr2:210,169,996–210,172,503 | 168.7 kb | Distal (>10kb) Multiome | 1015 | |
| chr2:210,181,086–210,182,197 | 179.1 kb | Distal (>10kb) Multiome | 168 | |
| chr2:210,224,566–210,225,799 | 222.5 kb | Distal (>10kb) Multiome | 493 |
Genomic view of the RPE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.