Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in PERK-mediated unfolded protein response and snRNA transcription. Located in cilium; cytosol; and nucleolus. Part of transcription preinitiation complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RPAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:92,029,331–92,030,637 | 268.9 kb | Distal (>10kb) Multiome | 471 | |
| chr1:92,079,936–92,081,084 | 218.6 kb | Distal (>10kb) Multiome | 692 | |
| chr1:92,298,519–92,299,563 | 125 bp | At TSS Multiome | 840 | |
| chr1:92,441,538–92,442,309 | 142.9 kb | Distal (>10kb) Multiome | 718 | |
| chr1:92,473,597–92,474,467 | 174.9 kb | Distal (>10kb) Multiome | 137 | |
| chr1:92,480,069–92,481,737 | 181.6 kb | Distal (>10kb) Multiome | 287 | |
| chr1:92,482,022–92,487,176 | 186.9 kb | Distal (>10kb) Multiome | 917 |
Genomic view of the RPAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.