This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for RNF19A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF19A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF19A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:100,105,612–100,106,523 | 203.9 kb | Distal (>10kb) Multiome | 186 | |
| chr8:100,145,361–100,146,165 | 164.1 kb | Distal (>10kb) Multiome | 584 | |
| chr8:100,149,973–100,150,933 | 159.4 kb | Distal (>10kb) Multiome | 732 | |
| chr8:100,157,695–100,158,647 | 151.8 kb | Distal (>10kb) Multiome | 728 | |
| chr8:100,212,742–100,213,750 | 96.9 kb | Distal (>10kb) Multiome | 792 | |
| chr8:100,309,111–100,310,745 | 198 bp | At TSS Multiome | 964 | |
| chr8:100,335,686–100,336,642 | 26.3 kb | Distal (>10kb) Multiome | 284 | |
| chr8:100,375,327–100,376,046 | 65.8 kb | Distal (>10kb) Multiome | 241 | |
| chr8:100,559,150–100,560,136 | 249.8 kb | Distal (>10kb) Multiome | 918 |
Genomic view of the RNF19A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.