Enables ubiquitin-protein transferase activity. Involved in positive regulation of DNA-templated transcription; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNF187. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF187 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF187, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:228,212,247–228,214,390 | 273.7 kb | Distal (>10kb) Multiome | 604 | |
| chr1:228,275,524–228,276,595 | 211.3 kb | Distal (>10kb) Multiome | 428 | |
| chr1:228,378,133–228,379,597 | 108.7 kb | Distal (>10kb) Multiome | 515 | |
| chr1:228,406,106–228,407,568 | 80.4 kb | Distal (>10kb) Multiome | 753 | |
| chr1:228,416,050–228,416,929 | 70.9 kb | Distal (>10kb) Multiome | 279 | |
| chr1:228,457,070–228,458,723 | 29.5 kb | Distal (>10kb) Multiome | 800 | |
| chr1:228,458,870–228,459,670 | 28.0 kb | Distal (>10kb) Multiome | 503 | |
| chr1:228,464,228–228,465,055 | 22.6 kb | Distal (>10kb) Multiome | 204 | |
| chr1:228,486,589–228,487,963 | 124 bp | At TSS Multiome | 1041 | |
| chr1:228,647,259–228,648,459 | 160.6 kb | Distal (>10kb) Multiome | 684 | |
| chr1:228,735,011–228,736,739 | 248.0 kb | Distal (>10kb) Multiome | 664 | |
| chr1:228,781,279–228,781,746 | 294.1 kb | Distal (>10kb) Multiome | 238 |
Genomic view of the RNF187 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.