The protein encoded by this gene belongs to the evolutionary conserved sif2 family of proteins that share the DUF155 domain in common. This protein is thought to be localized in the mitochondria and involved in mitochondrial translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-11. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for RMND1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RMND1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RMND1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:151,239,598–151,241,662 | 211.9 kb | Distal (>10kb) Multiome | 604 | |
| chr6:151,373,738–151,374,525 | 77.9 kb | Distal (>10kb) Multiome | 304 | |
| chr6:151,389,414–151,392,227 | 61.7 kb | Distal (>10kb) Multiome | 1234 | |
| chr6:151,451,713–151,453,312 | 133 bp | At TSS Multiome | 1109 | |
| chr6:151,454,144–151,454,386 | 2.0 kb | Proximal (<10kb) | 11 | |
| chr6:151,455,622–151,456,111 | 3.5 kb | Proximal (<10kb) | 72 | |
| chr6:151,456,653–151,457,328 | 4.9 kb | Proximal (<10kb) Multiome | 65 | |
| chr6:151,457,745–151,458,131 | 5.6 kb | Proximal (<10kb) | 13 | |
| chr6:151,493,661–151,494,985 | 42.0 kb | Distal (>10kb) Multiome | 691 | |
| chr6:151,589,007–151,590,183 | 137.6 kb | Distal (>10kb) Multiome | 147 | |
| chr6:151,646,686–151,647,288 | 194.9 kb | Distal (>10kb) Multiome | 84 | |
| chr6:151,647,848–151,649,022 | 196.3 kb | Distal (>10kb) Multiome | 205 | |
| chr6:151,683,003–151,684,338 | 231.5 kb | Distal (>10kb) Multiome | 214 |
Genomic view of the RMND1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.