RIT1

Ras like without CAAX 1 | MGC125864, MGC125865, RIBB, ROC1, RIT

This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Member of: DE-1 DE-1.3

Biological processes 16 terms

G protein activity (GO:0003925)GTP binding (GO:0005525)GTP binding (GO:0005525)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)Ras protein signal transduction (GO:0007265)Ras protein signal transduction (GO:0007265)calmodulin binding (GO:0005516)calmodulin binding (GO:0005516)membrane (GO:0016020)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)signal transduction (GO:0007165)signal transduction (GO:0007165)

Expression (TPM)

TFs regulating RIT1 0 TFs

Transcription factors with Perturb-seq knockdown data for RIT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RIT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:155,688,087–155,689,328	222.6 kb	Distal (>10kb) Multiome	838
chr1:155,745,339–155,745,870	165.8 kb	Distal (>10kb) Multiome	505
chr1:155,806,537–155,807,073	104.6 kb	Distal (>10kb) Multiome	15
chr1:155,856,932–155,857,529	54.2 kb	Distal (>10kb) Multiome	639
chr1:155,859,095–155,860,745	52.0 kb	Distal (>10kb) Multiome	632
chr1:155,910,686–155,911,579	33 bp	At TSS Multiome	691
chr1:155,934,107–155,934,787	23.1 kb	Distal (>10kb) Multiome	872
chr1:155,976,727–155,977,187	65.5 kb	Distal (>10kb) Multiome	316
chr1:155,977,296–155,979,264	67.3 kb	Distal (>10kb) Multiome	698
chr1:156,020,469–156,021,128	109.5 kb	Distal (>10kb) Multiome	558
chr1:156,052,923–156,055,358	143.5 kb	Distal (>10kb) Multiome	1053
chr1:156,060,806–156,061,738	149.8 kb	Distal (>10kb) Multiome	318
chr1:156,063,507–156,064,184	152.4 kb	Distal (>10kb) Multiome	199
chr1:156,076,488–156,077,355	165.6 kb	Distal (>10kb) Multiome	246
chr1:156,081,942–156,083,586	171.2 kb	Distal (>10kb) Multiome	670
chr1:156,105,879–156,107,316	195.2 kb	Distal (>10kb) Multiome	663
chr1:156,114,184–156,115,669	203.3 kb	Distal (>10kb) Multiome	824
chr1:156,123,520–156,124,091	212.4 kb	Distal (>10kb) Multiome	679
chr1:156,129,945–156,130,610	219.0 kb	Distal (>10kb) Multiome	733
chr1:156,146,058–156,146,760	234.9 kb	Distal (>10kb) Multiome	429
chr1:156,149,593–156,150,242	238.6 kb	Distal (>10kb) Multiome	194
chr1:156,160,602–156,161,218	249.7 kb	Distal (>10kb) Multiome	218
chr1:156,181,487–156,182,119	270.4 kb	Distal (>10kb) Multiome	145
chr1:156,184,002–156,185,155	273.0 kb	Distal (>10kb) Multiome	216
chr1:156,193,531–156,194,375	282.5 kb	Distal (>10kb) Multiome	751

Genome Browser

Genomic view of the RIT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.