Enables 14-3-3 protein binding activity. Involved in several processes, including establishment of Golgi localization; negative regulation of Rho guanyl-nucleotide exchange factor activity; and negative regulation of Rho protein signal transduction. Located in several cellular components, including Golgi apparatus; cell leading edge; and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RIPOR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIPOR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIPOR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,236,439–67,237,267 | 292.0 kb | Distal (>10kb) Multiome | 195 | |
| chr16:67,245,855–67,247,890 | 281.3 kb | Distal (>10kb) Multiome | 1077 | |
| chr16:67,248,206–67,249,338 | 279.7 kb | Distal (>10kb) Multiome | 467 | |
| chr16:67,262,177–67,262,869 | 266.3 kb | Distal (>10kb) Multiome | 24 | |
| chr16:67,278,724–67,279,792 | 249.4 kb | Distal (>10kb) Multiome | 869 | |
| chr16:67,326,413–67,327,343 | 202.0 kb | Distal (>10kb) Multiome | 585 | |
| chr16:67,393,199–67,393,789 | 135.3 kb | Distal (>10kb) Multiome | 377 | |
| chr16:67,399,230–67,399,872 | 129.2 kb | Distal (>10kb) Multiome | 211 | |
| chr16:67,415,996–67,416,812 | 112.4 kb | Distal (>10kb) Multiome | 687 | |
| chr16:67,428,012–67,428,783 | 100.5 kb | Distal (>10kb) Multiome | 382 | |
| chr16:67,430,407–67,432,610 | 97.7 kb | Distal (>10kb) Multiome | 790 | |
| chr16:67,480,508–67,481,841 | 47.6 kb | Distal (>10kb) Multiome HiCAR | 1002 | |
| chr16:67,521,086–67,521,812 | 7.4 kb | Proximal (<10kb) Multiome | 775 | |
| chr16:67,528,470–67,529,464 | 18 bp | At TSS Multiome | 641 | |
| chr16:67,530,176–67,530,600 | 1.4 kb | Proximal (<10kb) | 365 | |
| chr16:67,537,215–67,538,620 | 9.2 kb | Proximal (<10kb) Multiome | 560 | |
| chr16:67,547,027–67,547,277 | 9.6 kb | Proximal (<10kb) | 453 | |
| chr16:67,561,597–67,563,672 | 33.5 kb | Distal (>10kb) Multiome | 1044 | |
| chr16:67,644,719–67,645,304 | 116.1 kb | Distal (>10kb) Multiome HiCAR | 638 | |
| chr16:67,649,353–67,649,999 | 120.9 kb | Distal (>10kb) Multiome HiCAR | 112 | |
| chr16:67,652,610–67,653,810 | 124.2 kb | Distal (>10kb) Multiome HiCAR | 498 | |
| chr16:67,659,631–67,661,707 | 132.0 kb | Distal (>10kb) Multiome HiCAR | 962 | |
| chr16:67,666,180–67,667,235 | 137.8 kb | Distal (>10kb) Multiome HiCAR | 713 | |
| chr16:67,667,674–67,668,349 | 139.3 kb | Distal (>10kb) Multiome HiCAR | 628 | |
| chr16:67,718,772–67,720,138 | 190.5 kb | Distal (>10kb) Multiome | 866 | |
| chr16:67,806,066–67,807,386 | 277.9 kb | Distal (>10kb) Multiome | 914 | |
| chr16:67,816,404–67,816,888 | 287.9 kb | Distal (>10kb) Multiome | 690 | |
| chr16:67,884,566–67,885,097 | 356.1 kb | Distal (>10kb) Multiome HiCAR | 264 |
Genomic view of the RIPOR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.