The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
Transcription factors with Perturb-seq knockdown data for RIMS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIMS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIMS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:103,298,291–103,299,527 | 201.9 kb | Distal (>10kb) Multiome | 649 | |
| chr8:103,370,990–103,372,400 | 129.4 kb | Distal (>10kb) Multiome | 619 | |
| chr8:103,414,336–103,415,724 | 85.7 kb | Distal (>10kb) Multiome | 1010 | |
| chr8:103,498,473–103,502,003 | 784 bp | At TSS Multiome | 670 | |
| chr8:103,623,788–103,624,534 | 123.3 kb | Distal (>10kb) Multiome | 178 | |
| chr8:103,650,732–103,651,447 | 150.3 kb | Distal (>10kb) Multiome | 148 | |
| chr8:104,028,764–104,029,469 | 528.3 kb | Distal (>10kb) Multiome | 110 | |
| chr8:104,222,980–104,224,352 | 722.5 kb | Distal (>10kb) Multiome | 494 | |
| chr8:104,284,246–104,285,022 | 783.8 kb | Distal (>10kb) Multiome | 71 | |
| chr8:104,329,708–104,330,521 | 829.2 kb | Distal (>10kb) Multiome | 369 | |
| chr8:104,345,786–104,346,495 | 845.1 kb | Distal (>10kb) Multiome | 86 |
Genomic view of the RIMS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.