The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for RECK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RECK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RECK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:35,748,884–35,750,005 | 287.6 kb | Distal (>10kb) Multiome | 667 | |
| chr9:35,756,620–35,757,642 | 279.9 kb | Distal (>10kb) Multiome | 810 | |
| chr9:35,790,361–35,791,220 | 246.4 kb | Distal (>10kb) Multiome | 282 | |
| chr9:35,791,337–35,791,986 | 245.2 kb | Distal (>10kb) Multiome | 98 | |
| chr9:35,811,906–35,812,486 | 224.7 kb | Distal (>10kb) Multiome | 610 | |
| chr9:35,814,402–35,815,681 | 221.7 kb | Distal (>10kb) Multiome | 896 | |
| chr9:35,828,657–35,829,781 | 207.7 kb | Distal (>10kb) Multiome | 419 | |
| chr9:35,845,853–35,846,711 | 190.6 kb | Distal (>10kb) Multiome | 141 | |
| chr9:36,036,454–36,037,604 | 74 bp | At TSS Multiome | 528 | |
| chr9:36,118,241–36,119,014 | 81.5 kb | Distal (>10kb) Multiome | 47 | |
| chr9:36,135,958–36,137,395 | 99.7 kb | Distal (>10kb) Multiome | 462 | |
| chr9:36,163,065–36,163,901 | 126.5 kb | Distal (>10kb) Multiome | 343 | |
| chr9:36,166,123–36,166,839 | 129.7 kb | Distal (>10kb) Multiome | 515 | |
| chr9:36,188,047–36,188,562 | 151.4 kb | Distal (>10kb) Multiome | 13 | |
| chr9:36,190,463–36,191,342 | 153.9 kb | Distal (>10kb) Multiome | 863 | |
| chr9:36,257,896–36,258,893 | 221.4 kb | Distal (>10kb) Multiome | 891 |
Genomic view of the RECK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.