The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal cancer. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for RCC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RCC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RCC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:17,377,361–17,378,012 | 62.1 kb | Distal (>10kb) Multiome | 196 | |
| chr1:17,406,075–17,406,641 | 33.3 kb | Distal (>10kb) Multiome | 422 | |
| chr1:17,437,423–17,439,141 | 1.8 kb | Proximal (<10kb) Multiome | 678 | |
| chr1:17,439,507–17,440,088 | 149 bp | At TSS Multiome | 505 | |
| chr1:17,538,513–17,539,065 | 99.1 kb | Distal (>10kb) Multiome | 147 | |
| chr1:17,703,969–17,704,568 | 264.7 kb | Distal (>10kb) Multiome | 33 |
Genomic view of the RCC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.