This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for RBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:139,329,180–139,329,822 | 210.3 kb | Distal (>10kb) Multiome | 549 | |
| chr3:139,343,851–139,344,613 | 195.6 kb | Distal (>10kb) Multiome | 725 | |
| chr3:139,389,189–139,390,485 | 150.0 kb | Distal (>10kb) Multiome | 865 | |
| chr3:139,535,082–139,535,288 | 4.5 kb | Proximal (<10kb) | 113 | |
| chr3:139,537,906–139,538,860 | 881 bp | At TSS | 246 | |
| chr3:139,538,922–139,539,125 | 616 bp | At TSS | 75 | |
| chr3:139,539,215–139,540,395 | 7 bp | At TSS Multiome | 408 | |
| chr3:139,677,414–139,678,329 | 138.2 kb | Distal (>10kb) Multiome | 643 |
Genomic view of the RBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.