The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RBMS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBMS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBMS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:56,221,094–56,222,691 | 299.9 kb | Distal (>10kb) Multiome | 884 | |
| chr12:56,222,996–56,223,487 | 298.7 kb | Distal (>10kb) Multiome | 38 | |
| chr12:56,223,843–56,224,800 | 297.5 kb | Distal (>10kb) Multiome | 765 | |
| chr12:56,257,471–56,258,774 | 263.4 kb | Distal (>10kb) Multiome | 710 | |
| chr12:56,266,608–56,267,683 | 254.8 kb | Distal (>10kb) Multiome | 857 | |
| chr12:56,299,744–56,300,865 | 221.4 kb | Distal (>10kb) Multiome | 923 | |
| chr12:56,315,380–56,316,674 | 205.6 kb | Distal (>10kb) Multiome | 934 | |
| chr12:56,333,366–56,334,588 | 187.8 kb | Distal (>10kb) Multiome | 853 | |
| chr12:56,359,808–56,360,881 | 161.5 kb | Distal (>10kb) Multiome | 860 | |
| chr12:56,448,848–56,449,756 | 72.6 kb | Distal (>10kb) Multiome | 920 | |
| chr12:56,468,239–56,468,840 | 53.3 kb | Distal (>10kb) Multiome | 907 | |
| chr12:56,487,633–56,488,590 | 33.5 kb | Distal (>10kb) Multiome | 784 | |
| chr12:56,521,708–56,522,015 | at TSS | At TSS | 288 | |
| chr12:56,629,725–56,630,674 | 108.5 kb | Distal (>10kb) Multiome | 759 | |
| chr12:56,633,838–56,637,505 | 112.6 kb | Distal (>10kb) Multiome | 1037 | |
| chr12:56,645,530–56,646,466 | 124.3 kb | Distal (>10kb) Multiome | 902 | |
| chr12:56,687,276–56,689,898 | 167.8 kb | Distal (>10kb) Multiome | 1162 | |
| chr12:56,724,695–56,725,713 | 203.5 kb | Distal (>10kb) Multiome | 972 | |
| chr12:56,751,814–56,752,566 | 230.5 kb | Distal (>10kb) Multiome | 765 |
Genomic view of the RBMS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.