This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Apr 2009]
Transcription factors with Perturb-seq knockdown data for RBM19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:113,862,647–113,863,440 | 103.3 kb | Distal (>10kb) Multiome | 221 | |
| chr12:113,932,770–113,933,626 | 33.1 kb | Distal (>10kb) Multiome | 320 | |
| chr12:113,965,897–113,966,787 | 78 bp | At TSS Multiome | 723 | |
| chr12:115,163,558–115,164,209 | 1197.6 kb | Distal (>10kb) Multiome HiCAR | 98 | |
| chr12:115,451,794–115,452,615 | 1485.8 kb | Distal (>10kb) Multiome HiCAR | 393 | |
| chr12:115,916,891–115,917,494 | 1951.0 kb | Distal (>10kb) Multiome HiCAR | 363 |
Genomic view of the RBM19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.