The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for RB1CC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RB1CC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RB1CC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:52,413,690–52,414,600 | 300.4 kb | Distal (>10kb) Multiome | 185 | |
| chr8:52,564,497–52,566,289 | 148.9 kb | Distal (>10kb) Multiome | 374 | |
| chr8:52,629,074–52,630,030 | 84.8 kb | Distal (>10kb) Multiome | 275 | |
| chr8:52,713,424–52,715,199 | 98 bp | At TSS Multiome | 913 | |
| chr8:52,939,106–52,942,189 | 227.2 kb | Distal (>10kb) Multiome HiCAR | 558 | |
| chr8:53,842,551–53,843,618 | 1128.7 kb | Distal (>10kb) Multiome HiCAR | 936 | |
| chr8:53,879,185–53,882,655 | 1165.5 kb | Distal (>10kb) Multiome HiCAR | 721 |
Genomic view of the RB1CC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.