This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for RASSF8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASSF8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASSF8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:25,876,360–25,876,912 | 82.0 kb | Distal (>10kb) Multiome | 39 | |
| chr12:25,958,056–25,959,417 | 35 bp | At TSS Multiome | 529 | |
| chr12:26,065,293–26,065,889 | 107.0 kb | Distal (>10kb) Multiome | 70 | |
| chr12:26,088,833–26,089,365 | 130.3 kb | Distal (>10kb) Multiome | 80 | |
| chr12:26,113,933–26,115,170 | 155.8 kb | Distal (>10kb) Multiome | 955 | |
| chr12:26,121,816–26,123,629 | 164.0 kb | Distal (>10kb) Multiome | 439 | |
| chr12:26,124,811–26,126,830 | 167.8 kb | Distal (>10kb) Multiome | 661 | |
| chr12:26,195,307–26,196,297 | 237.1 kb | Distal (>10kb) Multiome | 353 |
Genomic view of the RASSF8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.