This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for RAP1GAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAP1GAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAP1GAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:2,511,517–2,512,317 | 243.8 kb | Distal (>10kb) Multiome | 698 | |
| chr17:2,592,971–2,594,792 | 162.1 kb | Distal (>10kb) Multiome | 853 | |
| chr17:2,691,692–2,692,319 | 63.7 kb | Distal (>10kb) Multiome | 66 | |
| chr17:2,710,909–2,712,254 | 43.9 kb | Distal (>10kb) Multiome | 864 | |
| chr17:2,716,507–2,717,103 | 38.9 kb | Distal (>10kb) Multiome | 112 | |
| chr17:2,723,482–2,725,106 | 31.7 kb | Distal (>10kb) Multiome | 477 | |
| chr17:2,749,134–2,750,125 | 5.9 kb | Proximal (<10kb) Multiome | 859 | |
| chr17:2,755,248–2,756,668 | 191 bp | At TSS Multiome | 347 | |
| chr17:2,776,093–2,777,278 | 21.1 kb | Distal (>10kb) Multiome | 372 | |
| chr17:2,786,083–2,786,614 | 30.7 kb | Distal (>10kb) Multiome | 526 | |
| chr17:2,852,945–2,854,316 | 98.0 kb | Distal (>10kb) Multiome | 362 | |
| chr17:2,874,180–2,874,725 | 118.7 kb | Distal (>10kb) Multiome | 101 | |
| chr17:2,929,950–2,930,517 | 174.5 kb | Distal (>10kb) Multiome | 170 | |
| chr17:3,048,574–3,049,576 | 293.3 kb | Distal (>10kb) Multiome | 636 |
Genomic view of the RAP1GAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.