Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for RALGPS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RALGPS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RALGPS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:178,541,715–178,543,543 | 182.4 kb | Distal (>10kb) Multiome HiCAR | 856 | |
| chr1:178,581,331–178,581,873 | 143.5 kb | Distal (>10kb) Multiome | 139 | |
| chr1:178,724,480–178,726,551 | 1.2 kb | Proximal (<10kb) Multiome | 861 | |
| chr1:178,727,718–178,727,919 | 2.5 kb | Proximal (<10kb) | 74 | |
| chr1:179,002,311–179,003,353 | 277.6 kb | Distal (>10kb) Multiome HiCAR | 522 |
Genomic view of the RALGPS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.