Predicted to enable GTPase binding activity. Acts upstream of or within substrate adhesion-dependent cell spreading. Located in microtubule. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RADIL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RADIL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RADIL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:4,625,503–4,626,335 | 257.7 kb | Distal (>10kb) Multiome | 189 | |
| chr7:4,631,373–4,632,184 | 251.9 kb | Distal (>10kb) Multiome | 464 | |
| chr7:4,641,264–4,642,525 | 241.8 kb | Distal (>10kb) Multiome | 1072 | |
| chr7:4,681,869–4,682,504 | 201.5 kb | Distal (>10kb) Multiome | 517 | |
| chr7:4,700,808–4,701,595 | 182.5 kb | Distal (>10kb) Multiome | 166 | |
| chr7:4,707,922–4,708,359 | 175.5 kb | Distal (>10kb) Multiome | 107 | |
| chr7:4,744,414–4,745,493 | 138.5 kb | Distal (>10kb) Multiome | 673 | |
| chr7:4,775,021–4,775,903 | 108.2 kb | Distal (>10kb) Multiome | 860 | |
| chr7:4,791,775–4,793,216 | 91.3 kb | Distal (>10kb) Multiome | 359 | |
| chr7:4,798,157–4,798,757 | 85.4 kb | Distal (>10kb) Multiome | 349 | |
| chr7:4,845,690–4,846,237 | 37.8 kb | Distal (>10kb) Multiome HiCAR | 165 | |
| chr7:4,882,152–4,884,513 | 13 bp | At TSS Multiome | 585 | |
| chr7:4,973,785–4,974,732 | 90.4 kb | Distal (>10kb) Multiome | 674 | |
| chr7:5,045,501–5,046,448 | 162.1 kb | Distal (>10kb) Multiome | 594 |
Genomic view of the RADIL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.