Enables GTPase activator activity and small GTPase binding activity. Acts upstream of or within regulation of protein localization. Located in several cellular components, including Golgi apparatus; cilium; and early endosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RABGAP1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RABGAP1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RABGAP1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:174,799,347–174,800,510 | 74.7 kb | Distal (>10kb) Multiome | 456 | |
| chr1:174,871,376–174,871,876 | 2.6 kb | Proximal (<10kb) | 36 | |
| chr1:174,871,982–174,872,144 | 2.3 kb | Proximal (<10kb) | 87 | |
| chr1:174,874,263–174,874,768 | at TSS | At TSS | 189 | |
| chr1:174,875,290–174,875,766 | 833 bp | At TSS | 158 | |
| chr1:174,882,897–174,883,845 | 9.0 kb | Proximal (<10kb) Multiome | 184 | |
| chr1:174,976,347–174,977,217 | 102.3 kb | Distal (>10kb) Multiome | 181 | |
| chr1:174,998,565–175,000,705 | 125.3 kb | Distal (>10kb) Multiome HiCAR | 1242 | |
| chr1:175,022,930–175,024,023 | 149.0 kb | Distal (>10kb) Multiome | 878 | |
| chr1:175,029,423–175,030,223 | 155.4 kb | Distal (>10kb) Multiome | 562 | |
| chr1:175,073,610–175,074,084 | 199.4 kb | Distal (>10kb) Multiome | 76 | |
| chr1:175,129,648–175,130,843 | 255.8 kb | Distal (>10kb) Multiome | 246 | |
| chr1:175,146,568–175,147,254 | 272.3 kb | Distal (>10kb) Multiome | 324 | |
| chr1:175,151,904–175,152,560 | 277.8 kb | Distal (>10kb) Multiome | 185 | |
| chr1:175,154,371–175,155,390 | 280.6 kb | Distal (>10kb) Multiome | 333 |
Genomic view of the RABGAP1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.