The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for RAB25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:155,806,537–155,807,073 | 254.4 kb | Distal (>10kb) Multiome | 15 | |
| chr1:155,856,932–155,857,529 | 203.9 kb | Distal (>10kb) Multiome | 639 | |
| chr1:155,859,095–155,860,745 | 201.7 kb | Distal (>10kb) Multiome | 632 | |
| chr1:155,910,686–155,911,579 | 149.8 kb | Distal (>10kb) Multiome | 691 | |
| chr1:155,934,107–155,934,787 | 126.7 kb | Distal (>10kb) Multiome | 872 | |
| chr1:155,976,727–155,977,187 | 84.3 kb | Distal (>10kb) Multiome | 316 | |
| chr1:155,977,296–155,979,264 | 82.4 kb | Distal (>10kb) Multiome | 698 | |
| chr1:156,020,469–156,021,128 | 40.2 kb | Distal (>10kb) Multiome HiCAR | 558 | |
| chr1:156,052,923–156,055,358 | 6.3 kb | Proximal (<10kb) Multiome | 1053 | |
| chr1:156,060,806–156,061,738 | 42 bp | At TSS Multiome | 318 | |
| chr1:156,063,507–156,064,184 | 2.7 kb | Proximal (<10kb) Multiome | 199 | |
| chr1:156,065,858–156,066,603 | 4.7 kb | Proximal (<10kb) | 225 | |
| chr1:156,076,488–156,077,355 | 15.9 kb | Distal (>10kb) Multiome | 246 | |
| chr1:156,081,942–156,083,586 | 21.4 kb | Distal (>10kb) Multiome | 670 | |
| chr1:156,105,879–156,107,316 | 45.4 kb | Distal (>10kb) Multiome | 663 | |
| chr1:156,114,184–156,115,669 | 53.5 kb | Distal (>10kb) Multiome | 824 | |
| chr1:156,123,520–156,124,091 | 62.6 kb | Distal (>10kb) Multiome | 679 | |
| chr1:156,129,945–156,130,610 | 69.3 kb | Distal (>10kb) Multiome | 733 | |
| chr1:156,146,058–156,146,760 | 85.2 kb | Distal (>10kb) Multiome | 429 | |
| chr1:156,149,593–156,150,242 | 88.8 kb | Distal (>10kb) Multiome | 194 | |
| chr1:156,160,602–156,161,218 | 99.9 kb | Distal (>10kb) Multiome | 218 | |
| chr1:156,181,487–156,182,119 | 120.6 kb | Distal (>10kb) Multiome | 145 | |
| chr1:156,184,002–156,185,155 | 123.2 kb | Distal (>10kb) Multiome | 216 | |
| chr1:156,193,531–156,194,375 | 132.8 kb | Distal (>10kb) Multiome | 751 | |
| chr1:156,212,611–156,213,686 | 152.0 kb | Distal (>10kb) Multiome | 893 | |
| chr1:156,245,413–156,246,269 | 184.6 kb | Distal (>10kb) Multiome | 380 | |
| chr1:156,282,165–156,283,323 | 221.7 kb | Distal (>10kb) Multiome | 973 | |
| chr1:156,291,233–156,291,857 | 230.4 kb | Distal (>10kb) Multiome | 518 | |
| chr1:156,337,825–156,339,056 | 277.3 kb | Distal (>10kb) Multiome | 836 | |
| chr1:156,356,873–156,357,393 | 295.9 kb | Distal (>10kb) Multiome | 506 |
Genomic view of the RAB25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.