This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for RAB13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:153,697,776–153,698,654 | 288.0 kb | Distal (>10kb) Multiome | 313 | |
| chr1:153,727,492–153,728,827 | 258.5 kb | Distal (>10kb) Multiome | 702 | |
| chr1:153,736,782–153,737,426 | 249.3 kb | Distal (>10kb) Multiome | 10 | |
| chr1:153,745,487–153,745,959 | 240.7 kb | Distal (>10kb) Multiome | 55 | |
| chr1:153,774,962–153,776,698 | 211.2 kb | Distal (>10kb) Multiome | 671 | |
| chr1:153,783,341–153,784,300 | 202.6 kb | Distal (>10kb) Multiome HiCAR | 794 | |
| chr1:153,922,213–153,923,779 | 63.3 kb | Distal (>10kb) Multiome | 856 | |
| chr1:153,945,717–153,947,118 | 39.7 kb | Distal (>10kb) Multiome | 866 | |
| chr1:153,957,828–153,959,103 | 27.7 kb | Distal (>10kb) Multiome | 912 | |
| chr1:153,963,107–153,964,407 | 22.7 kb | Distal (>10kb) Multiome | 798 | |
| chr1:153,967,147–153,968,324 | 18.7 kb | Distal (>10kb) Multiome | 986 | |
| chr1:153,977,057–153,978,034 | 8.7 kb | Proximal (<10kb) Multiome | 853 | |
| chr1:153,985,902–153,987,184 | 87 bp | At TSS Multiome | 572 | |
| chr1:153,990,402–153,991,082 | 4.4 kb | Proximal (<10kb) Multiome | 950 | |
| chr1:154,182,339–154,183,774 | 197.0 kb | Distal (>10kb) Multiome | 934 | |
| chr1:154,220,079–154,221,864 | 234.4 kb | Distal (>10kb) Multiome | 1071 | |
| chr1:154,272,082–154,272,847 | 286.1 kb | Distal (>10kb) Multiome | 834 |
Genomic view of the RAB13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.