Enables GDP binding activity. Predicted to be involved in several processes, including endocytic recycling; endosome to lysosome transport; and positive regulation of macroautophagy. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in lysosome; phagocytic vesicle; and recycling endosome membrane. Predicted to be active in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RAB12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:8,367,255–8,367,704 | 242.0 kb | Distal (>10kb) Multiome | 314 | |
| chr18:8,608,780–8,609,797 | 176 bp | At TSS Multiome | 603 | |
| chr18:8,622,344–8,623,165 | 13.3 kb | Distal (>10kb) Multiome | 162 | |
| chr18:8,661,718–8,663,453 | 53.2 kb | Distal (>10kb) Multiome | 369 | |
| chr18:8,704,354–8,706,945 | 95.7 kb | Distal (>10kb) Multiome | 610 | |
| chr18:8,707,025–8,707,559 | 97.9 kb | Distal (>10kb) Multiome | 299 |
Genomic view of the RAB12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.